Name:

Neurogenomics and neuronal physiopathology

Leader:

• Frédéric Laumonnier

Research axis :

Identification and characterization of clinical, genetic, molecular and physiopathological markers targeting glutamatergic connexions and glutamate metabolism in two brain disorders appearing in periods far apart in neuronal and CNS development: Intellectual Disability (ID) during neurodevelopment, and Amyotrophic Lateral Sclerosis (ALS) during early neuronal aging.

Keywords: Human neurogenetics, neurosciences, neuronal cellular models, metabolomics, neuronal physiopathology, glutamatergic synapse

Expertise / know-how:

Gene sequencing (NGS), gene expression analyses, preparation and transfection of primary neuronal cultures (hippocampal, cortical neurons, motoneurons), cellular neurobiology (synaptic morphology, confocal microscopy), metabolomics, animal models.

Location:

Faculty of Medicine, Planiol building 3rd floor, 10 bd Tonnellé,  37000 Tours

Website:

https://ibrain.univ-tours.fr/english-version/neurogenomics-and-neuronal-physiopathology-1