Teams/Research groups

Lymphocytes differentiation, tolerance and metabolism: basis for immunotherapy

IMG 1447 1

Name:

Lymphocytes differentiation, tolerance and metabolism: basis for immunotherapy

Leader:

  • Martin Villalba

Research axis :

  • Onco-immunotherapy
  • Immunometabolism
  • Immunotherapy of inflammatory diseases:autoimmunity
  • specific anti-HLA antibodies toxicity,
  • endothelial cell activation,
  • complement transplantation,
  • antibody mediated rejection,
  • thrombotic microangiopathy.

Expertise / know-how:

  • Generation of in vitro expanded NK cells.
  • Studies in Natural cytotoxicity
  • Antibody-dependent cell cytotoxicity (ADCC)
  • Changes in metabolism and studies on metabolism
  • CD8+ and CD4+ T cell characterization
  • Mouse models of autoimmunity and immune tolerance
  • Glycosylation of antibodies: analysis by mass spectrometry
  • In vitro endothelial cells activation
  • Complement implication in antibody mediated rejection, endothelial cells activation
  • Complement  (C5b9, C3, membrane complement regulators ) immunoperoxidase staining

Location:

INSERM Centre: U1183 “Cellules souches, plasticité cellulaire, médecine régénératrice et immunothérapies”. Institute for Regenerative Medicine and Biotherapy (IRMB).

CHU Montpellier Hôpital Saint-Eloi

80, av. Augustin Fliche.

34295 Montpellier Cedex 5 France

Website:

http://www.irmb-inserm.fr/equipe-4.html