Teams/Research groups

T2i: Transplantation, Immunology and Inflammation

Name:

Transplantation, Immunology and Inflammation T2i - EA 4245 - Tours

Leader:

  • Pr Christophe BARON, PU-PH

Research axis :

  • Study of the immuno-inflammatory response in organ transplantation and during ischemia reperfusion.
  • Identification of biomarkers of organ dysfunction (tissue injury, rejection, relapse).
  • Development of new therapeutic strategies (antibodies and pharmacological agents) to prevent tissue damage.

Expertise / know-how:

  • Analysis of the immune-inflammatory response under normal conditions or hypoxia / reoxygenation : proliferation, viability, cytokines, adhesion/migration, multi-staining by flow cytometry, cytotoxicity…
  • Culture of cancer cells (mammary and colon epithelial origin) ; Establishment of primary colorectal cultures from biopsies ; Differentiation of human monocytes into dendritic cells ; Culture of cardiomyocytes and cardiac fibroblasts, renal tubular proximal cells.
  • Immortalization by EBV technique and culture of human B lymphocytes
  • Cell sorting : “single cell”

Location:

Bat Vialle, UFR Medicine, University of Tours, France

BCR Facility level -1 bâtiment Bretonneau, UFR Medicine