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Proteolytic Mechanisms in Inflammation

Name:

Proteolytic Mechanisms in Inflammation - U1100 - Tours

Leader:

  • Gilles Lalmanach

Research axis :

The team studies proteolytic processes involved in inflammatory lung diseases according different axes. The first one concerns the study of the proteolytic activities of serine and cysteine proteases in lung inflammation while the second focuses on the development of targetting strategies of extracellular proteases using either protease inhibitors or neutralizing antibodies. The ability of antibodies to discriminate between highly similar proteases could be of great use for therapeutic approaches that target MMP-12 in chronic obstructive pulmonary disease (COPD) or protease 3, a neutrophil serine protease involved in granulomatosis with polyangiitis.

Expertise / know-how:

  • Enzymology
  • Biochemistry of peptides and proteins
  • Recombinant protein expression
  • Structure-function relationship analysis
  • Bioinformatics/ Molecular modeling

Location:

Centre d’Etude des Pathologies Respiratoires INSERM U1100
Faculté de Médecine
10, Bd Tonnelle BP 3223
37032 TOURS cedex

Website:

https://cepr.inserm.univ-tours.fr/english-version/teams/team-inserm-2-br-g-lalmanach