Flagship project KQ4

Strategies to overcome biological barriers and improve therapeutic antibodies biodistribution

Biological, chemical and physical barriers associated to pathological conditions can interfere with Ab. The project aims at understanding and proposing strategies to overcome these barriers.

Teams involved in the project and their tasks:

• Antibodies and tumoral barriers
  • Radiobiology and Targeted Radiotherapy – IRCM – Montpellier
  • Functional screening and targeting in cancer – IRMC – Montpellier
• Fc/FcRn and barriers crossing
  • Fc Receptors, Antibodies and MicroEnvironment – EA7501 – Tours
• Antibodies and extracellular barriers (proteases, mucus,…)
  • Aerosoltherapy and biologics for respiratory diseases – U1100 – Tours

Objectives of the project:

Developing strategies to improve the biodistribution of Ab at the target level, and in fine the therapeutic response.