KQ2 – How can antibody activity be optimised by adjusting format?
(Gilles Uzé, Valérie Gouilleux-Gruart, Martine Cerutti)
Our objectives are to understand the mechanism of action of therapeutic antibodies and to adjust their format accordingly, in order to achieve optimal activity. Our work implicates research into novel formats which:
- Modulate antibody pharmacokinetics, particularly via interaction with the neonatal Fc receptor (FcRn)
- Modulate effector functions, in particular those involving FcgRs or the complement system
- Carry additional modules that alter the properties of target cells