KQ1- How can target activity be modulated through antibody binding?
(Pierre Martineau, Eric Reiter, Florence Velge-Roussel)
Certain antibodies, including those under development in the LabEx, can be used to modify the biological activity of their targets. Our objectives are to study these agents, in order to understand the underlying processes and to develop tools to analyse these interactions. Our work includes:
- In silico modelling of paratope/epitope interactions
- Investigation of the relationship between the structure of this defined interface and activity
- Functional screening and characterisation of antibody activity: antagonists v agonists; orthosteric v allosteric modulators; biased agonists
- Maturation of the affinity/kon/koff and study of its impact on the properties of the target